NanoBio Awarded Grant for Development of Genital Herpes Vaccine

Lauren Santye, Assistant Editor
Published Online: Tuesday, March 7th, 2017
NanoBio Corporation was awarded a 2-year phase 2 Small Business Research Innovation (SBIR) grant for the development of an intranasal nanoemulsion (NE) adjuvant vaccine for genital herpes prevention.
The grant was given by the National Institute of Allergy and Infectious Diseases (NIAID) and will fund up to $1.5 million of critical preclinical research and development activities, including the completion of a pre-IND meeting with the FDA, according to a company press release.
Genital herpes is most commonly caused by the herpes simplex virus-2 (HSV-2), and infections are lifelong. The virus is often asymptomatic causing transmission between partners and mother-to-child transmission. Furthermore, studies have shown an association between genital herpes and the increased risk of HIV acquisition.
Individuals with HIV and herpes are more likely to pass on HIV because the presence of herpes increases HIV viral load, according to NAM. Furthermore, HIV-negative individuals with herpes blisters have an increased vulnerability to HIV infection.
The grant was based on experiments using NanoBio’s intranasal NE vaccine in several guinea pig challenge studies, according to the release.
“NanoBio’s intranasal vaccine is one of the only vaccine candidates we’ve studies that has shown efficacy in both the prophylactic and the therapeutic animal models,” investigator Dr David Bernstein, professor of pediatrics at Cincinnati Children’s Hospital Medical Center, said in the release. “Based on our data with this unique approach, we look forward to seeing the intranasal NE vaccine progress to human clinical studies.”
During the prophylactic guinea pig study, the investigators found that the intranasal NE HSV-2 vaccine prevented infection and viral latency in 92% of animals vaccinated, compared with 8% who received no treatment (control).
A separate therapeutic study, animals with recurrent HSV-2 infection were vaccinated with the intranasal NE vaccine. During the post-vaccination observation period, the investigators found that the vaccine reduced recurrent lesions and viral shedding by more than 50% compared with the control arm. There were no adverse events observed in any of the animals that were administered the NE HSV-2 vaccine.
“The phase 2 SBIR grant is a testament to the potential of NanoBio’s intranasal NE vaccine for genital herpes,” Dr Ali Fattom, senior vice president of vaccine research and development at NanoBio, said in the company release. “The funding enables the next step in the development research process.
“Throughout the past several years, we have consistently observed that our intranasal vaccine elicits both a serum and a mucosal immune response in animals. This differentiates our program from the many intramuscular HSV-2 vaccines in development. NanoBio’s intranasal NE vaccine provides protection both systemically and in mucosal tissues at the port of entry for the herpes virus. Based on preclinical data to date, we believe the first line of defense is essential to adequately protect against genital herpes.”
The CDC estimates more than 24 million individuals in the United States are infected with HSV-2, with 776,000 new infections each year. Currently, there are no approved vaccinations to prevent the disease.

Current Issue

The Educated Patient

Bethany Rettberg, NPC
Practitioners should get a detailed medical history and conduct a thorough physical to treat sinus infections.
Jennifer L. Hofmann, MS, PA-C
Providing them with advice can improve control of the disease and reduce hospitalizations, morbidity, and unscheduled health care visits.
Emily C. Hayes, PharmD Candidate
Colds, coughs, and a relentless influx of sick patients in retail health clinics keep the health care providers who work there very busy.
Kristen Marjama, DNP, APRN-BC
Although the rate of foot and leg amputation has greatly declined over the past 2 decades, increasing awareness for macrovascular and microvascular complications of diabetes is essential because diabetes is the leading cause of lower-limb amputations in the United States.
$vacMongoViewPlus$ $vAR$
Contemporary Clinic
MJH Associates
American Journal of Managed Care
MD Magazine
Pharmacy Times
Specialty Pharmacy Times
Targeted Oncology
About Us
Contact Us
Terms & Conditions
Pharmacy Healthcare & Communications, LLC
2 Clarke Drive
Suite 100
Cranbury, NJ 08512
P: 609-716-7777
F: 609-257-0701

Copyright Contemporary Clinic 2019
Pharmacy Healthcare & Communications, LLC. All Rights Reserved.