Live Attenuated Influenza Vaccine Ineffective in 2015-2016 Season

Jennifer Barrett, Assistant Editor
Published Online: Wednesday, August 16th, 2017
Overall, influenza vaccines reduced the number of influenza illnesses in the 2015-2016 season. However, the live attenuated influenza vaccine (LAIV) was shown to be ineffective in children during this time, according to a recently-published study. 

 Researchers from the Influenza Vaccine Effectiveness Network published their findings in the New England Journal of Medicine. For the study, the study researchers enrolled patients aged 6 months and older who presented with acute respiratory illness at study-site clinics during the 2015-16 flu season. To determine vaccine effectiveness, the researchers used a test-negative design to estimate effectiveness as the odds of testing positive for flu in both vaccinated and unvaccinated patients.
Of the 6,879 participants, 19% tested positive for influenza. Most of the flu illnesses included the 2009 H1N1 and influenza B strains. The researchers determined that, overall, the flu vaccine efficacy was 48%. In children aged 2-17 years old, the inactivated flu vaccine showed 60% effectiveness, but the researchers saw no effectiveness for the LAIV.
Since the 2016-2017 A(H1N1)pdm09 strain used in the LAIV was unchanged from the previous season, the Advisory Committee on Immunization Practices recommended against the use of the live attenuated influenza vaccine in its 2017 updated adult immunization recommendations.
Jackson ML, Chung JR, Jackson LA, et al. Influenza vaccine effective in the United States during the 2015-2016 season. N Engl J Med. 2017. 377:534-543. DOI: 10.1056/NEJMoa1700153

Current Issue

The Educated Patient

Kristen Marjama, DNP, APRN-BC
Although the rate of foot and leg amputation has greatly declined over the past 2 decades, increasing awareness for macrovascular and microvascular complications of diabetes is essential because diabetes is the leading cause of lower-limb amputations in the United States.
Kristen Marjama, DNP, FNP-BC
Gluten proteins found in barley, rye, and wheat trigger systemic injury primarily to the small intestine, but they can also affect the joints, liver, skin, uterus, and other organs.
Kristen Marjama, DNP, FNP-BC
It is that time of year again, when health care providers see an increase in patient volume because no one has time to be sick.
Sara Marlow, MSN, RN, PHN, FNP-C
Sunburn is still a major health issue that can be prevented.
$vacMongoViewPlus$ $vAR$
Contemporary Clinic
MJH Associates
American Journal of Managed Care
MD Magazine
Pharmacy Times
Specialty Pharmacy Times
Targeted Oncology
About Us
Contact Us
Terms & Conditions
Pharmacy Healthcare & Communications, LLC
2 Clarke Drive
Suite 100
Cranbury, NJ 08512
P: 609-716-7777
F: 609-257-0701

Copyright Contemporary Clinic 2018
Pharmacy Healthcare & Communications, LLC. All Rights Reserved.